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Search Results for " apoptosis-specific protein "

Targets Recommended: Apoptosis NADPH-oxidase

15

抑制剂 & 化合物

4

天然产物

3

化合物库

35

重组蛋白

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Cat. No.	Product Name
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L9420	外泌体相关化合物库		76 compounds
	76 种外泌体相关的化合物，可以用于高通量和高内涵筛选；

化合物库

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

外泌体相关化合物库

Cat.No: L9420

Compounds: 76

Cat. No.	Product Name	Target	Signaling Pathways
T29097	VAS 3947 VA-S3947,VA S3947,VAS3947	Apoptosis; NADPH-oxidase	Apoptosis; Immunology/Inflammation
	VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂。VAS 3947具有强大的抗血小板作用, 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡。
T6248	XL888	HSP	Cytoskeletal Signaling; Metabolism
	XL888 是一种 ATP 竞争性的 Hsp90 抑制剂，IC50值为 24 nM。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
TQ0081	JPH203 KYT-0353	Others	Others
	JPH203 (KYT-0353) 是一种 L 型氨基酸转运蛋白 1 (LAT-1) 的抑制剂，具有有效性和特异性。JPH203 可以抑制细胞对亮氨酸的摄取，抑制细胞增殖、诱导细胞凋亡，具有抗炎和抗肿瘤活性。
T16087	Quiflapon 喹夫拉朋,MK-591	Apoptosis; FLAP	Apoptosis; Immunology/Inflammation
	Quiflapon (MK-591) 是一种选择性和特异性的FLAP 抑制剂，可诱导细胞凋亡。它也是口服白三烯生物合成抑制剂，在完整的人和诱导的大鼠多形核白细胞 PMNLs 中，其IC50值分别为 3.1 nM 和 6.1 nM。
T22070	DBIBB	LPA Receptor	GPCR/G Protein
	DBIBB 是一种特异性溶血磷脂酸 (LPA2) 的 2 型 G 蛋白偶联受体的非脂质激动剂，是一种能够治疗高强度γ 射线对造血和胃肠系统引起的急性放射综合征的潜在活性分子，是一种作未有机合成和药物研究中的中间体。 DBIBB 可用于制备各种化合物，可减轻胃肠道辐射综合征，增加肠隐窝存活率和肠细胞增殖，并减少细胞凋亡。
T61106	GRP78-IN-1
	GRP78-IN-1 displays interactions with specific residues on the GRP78 protein with a binding energy of -8.07 kcal/mol. This compound possesses potent cytotoxic and anti-proliferative effects on cancer cells, particularly demonstrating promising apoptosis in breast cancer cells and wound healing properties [1].
T75931	Difopein TFA
	Difopein (TFA) 为14-3-3 protein（一种高度保守的真核调节分子）的特异性竞争性抑制剂，有效阻断14-3-3与其靶蛋白的结合，并抑制二者之间的相互作用。通过这一机制，Difopein (TFA) 能够诱导细胞程序性死亡(apoptosis)并增强顺铂对细胞的杀伤作用。
TP1551	Difopein TFA (396834-58-5 free base) Difopein TFA
	Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to inductio
T62977	MA242 free base
	MA242 free base 是一种特异性的 MDM2 和 NFAT1 双重抑制剂，能够诱导胰腺癌细胞系的凋亡。MA242 free base 以高亲和力直接结合 MDM2 和 NFAT1，诱导 MDM2 和 NFAT1 蛋白降解，抑制 NFAT1 介导的 MDM2 转录。
T73257	USP7-IN-9
	USP7-IN-9是一种高效USP7抑制剂，其IC50值为40.8 nM。该化合物可诱导RS4; 11 细胞发生(apoptosis)，并使细胞周期在G0/G1及S期停滞。此外，USP7-IN-9能够降低癌症相关蛋白MDM2和DNMT1的表达量，同时增加抑癌蛋白p53与p21的表达量。
T78296	IMAB027 ASP1650
	IMAB027 (ASP1650)是针对CLDN6 (Claudin 6)的特异性单克隆抗体，CLDN6作为一种紧密连接蛋白，其在多种人类癌症中异常高表达，尤其显著于卵巢癌。IMAB027展现出抗肿瘤特性，并能诱导表达CLDN6的卵巢癌和睾丸癌细胞走向凋亡。
T78055	MYC-RIBOTAC	c-Myc	Cell Cycle/Checkpoint
	MYC-RIBOTAC 是一种针对MYC内部核糖体进入位点（IRES）的核糖核酸酶靶向降解剂（RIBOTAC）。该化合物结合了MYC mRNA的靶向组分以及一种可招募并激活RNA酶L1的小分子。通过降低MYC的mRNA和蛋白质表达水平，MYC-RIBOTAC诱导细胞发生凋亡，应用于抗肿瘤治疗的研究。
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...
T36894	5-Bromouridine
	5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions....

化合物

Cat.No: T29097

Synonym: VA-S3947,VA S3947,VAS3947

Target: Apoptosis, NADPH-oxidase

Cat.No: T6248

Target: HSP

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cat.No: TQ0081

Synonym: KYT-0353

Target: Others

Cat.No: T16087

Synonym: 喹夫拉朋,MK-591

Target: Apoptosis, FLAP

Cat.No: T22070

Target: LPA Receptor

Cat.No: T61106

Cat.No: T75931

Difopein TFA (396834-58-5 free base)

Cat.No: TP1551

Synonym: Difopein TFA

MA242 free base

Cat.No: T62977

Cat.No: T73257

Cat.No: T78296

Synonym: ASP1650

Cat.No: T78055

Target: c-Myc

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Cat.No: T36894

Cat. No.	Product Name	Target	Signaling Pathways
T11665	Ionomycin calcium SQ23377 calcium,罗红霉素钙盐(链霉菌属载体)	Apoptosis; Calcium Channel; Antibacterial; Antibiotic; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Ionomycin calcium (SQ23377 calcium) 是选择性钙离子载体，也是一种由 Streptomyces conglobatus 产生的抗生素。它对二价阳离子具有高度特异性，还诱导蛋白激酶 C 激活。Ionomycin 促进细胞凋亡。
T1719	Bufalin	ATPase	Membrane transporter/Ion channel
	Bufalin 是蟾酥中的一种成分，是Na+/K+-ATPase 抑制剂，具有抗肿瘤活性，可与其基 α1、α2 和 α3 结合，Kd 值分别为 42.5、45 和 40 nM。
T16381	Okadaic acid	Others	Others
	Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halic
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...

天然产物

Ionomycin calcium

Cat.No: T11665

Synonym: SQ23377 calcium,罗红霉素钙盐(链霉菌属载体)

Target: Apoptosis, Calcium Channel, Antibacterial, Antibiotic, PKC

Cat.No: T1719

Target: ATPase

Cat.No: T16381

Target: Others

Phosphatidylserines (bovine)

Cat.No: T35577

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01329	ATG5 Protein, Human, Recombinant ASP,APG5L,Apoptosis-specific protein	Human	E. coli
	ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an impor...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPY-02078	HtrA2/Omi Protein, Human, Recombinant (His) PARK13,OMI,HtrA serine peptidase 2,PRSS25	Human	E. coli
	Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor...
TMPY-05058	TMX1 Protein, Human, Recombinant (mFc) thioredoxin-related transmembrane protein 1,PDIA11,...	Human	HEK293 Cells
	As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in the degradative pathways.
TMPJ-00770	Granzyme B/GZMB Protein, Mouse, Recombinant (His) Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,Granzyme ...	Mouse	HEK293 Cells
	Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
TMPK-01523	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein*, Human&Mouse, MHC (His & Avi) WAGR,WT33,AWT1,GUD,RMF,WT1,WIT-2,MHC,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein* is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRSF10B,TRIC...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPK-01554	HLA-A02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein*, Human, MHC (His & Avi) WT1,WT33,WIT-2,NPHS4GUD,AWT1,GUD,WAGR,MHC,RMF	Human	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein* is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01522	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein*, Human&Mouse, MHC (His & Avi) RMF,WT33,WIT-2,MHC,WAGR,AWT1,GUD,WT1,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein* is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01548	HLA-A02:01&B2M&WT-1 (RMFPNAPYL) Monomer Protein*, Human, MHC (His & Avi), Biotinylated MHC,WIT-2,AWT1,GUD,WAGR,WT1,NPHS4GUD,WT33,RMF	Human	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein* is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01549	HLA-A02:01&B2M&WT-1 (RMFPNAPYL) Monomer Protein*, Human, MHC (His & Avi) RMF,WAGR,MHC,GUD,NPHS4GUD,WT1,WT33,WIT-2,AWT1	Human	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein* is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPJ-01059	CRADD Protein, Human, Recombinant Caspase and RIP Adapter with Death Domain,RAIDD,RIP-Associat...	Human	E. coli
	Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numero...
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fas-li...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleu...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPY-01841	Serpin I2 Protein, Human, Recombinant (His) PI14,TSA2004,PANCPIN,MEPI,Serpin I2,serpin peptidase inhibit...	Human	HEK293 Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chy...
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated AXLLG,Growth arrest-specific protein 6,AXL...	Human	HEK293 Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat...
TMPY-01176	cIAP1 Protein, Human, Recombinant (Avi) Hiap-2,API1,HIAP2,RNF48,baculoviral IAP repeat containing 2,...	Human	E. coli
	The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase...
TMPH-02222	TEAD1 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPY-02640	FAM3B Protein, Human, Recombinant (hFc) PANDER,ORF9,PRED44,C21orf11,C21orf76,42056,family with seque...	Human	HEK293 Cells
	Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and beta- cells of pancreatic islets, insulin-secreting beta-TC3 cells, and glucagon-secreting alpha-TC cells. FAM3B causes apoptosis of beta-cells as assessed by electron microscopy, annexin Ⅴ fluorescent staining, and flow-cytometric terminal deoxynucleotidyl transferase-mediated dU...
TMPJ-01074	PKCE Protein, Human, Recombinant (His) PRKCE,PKCE,nPKC-ε,nPKC-Epsilon,Protein Kinase C Eps...	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has m...
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N...	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc) AXLLG,Gas6,GAS-6,AXLLGAXL stimulatory factor,growth arrest-<...	Human	HEK293 Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPY-04999	GAS6 Protein, Human, Recombinant (His)	Human	HEK293
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPJ-01097	ZBTB17 Protein, Human, Recombinant (His) MIZ1,ZNF60,Myc-Interacting Zinc Finger Protein 1,ZN...	Human	E. coli
	Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific genes, it has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. ZBTB17 may has growth arrest activity, probably through inhibition of cell cycle progression. ZBTB17 required for early embryonic development during gastrul...
TMPY-03498	ING4 Protein, Human, Recombinant (His) inhibitor of growth family, member 4,p29ING4,my036	Human	E. coli
	ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP3/p3, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activi...
TMPY-01416	OLFM4 Protein, Human, Recombinant (His) hGC-1,GC1,OLM4,bA209J19.1,GW112,olfactomedin 4,OlfD,hOLfD,UN...	Human	HEK293 Cells
	Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed...
TMPJ-01081	Dtk Protein, Human, Recombinant (His) RSE,SKY,DTK,Tyrosine-protein kinase DTK,Tyrosine-	Human	HEK293 Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th...
TMPY-01775	AIM2 Protein, Human, Recombinant (GST) absent in melanoma 2,PYHIN4	Human	Baculovirus Insect Cells
	AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting...
TMPY-04936	BCL2A1 Protein, Human, Recombinant (His) BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protein	Human	E. coli
	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der...
TMPY-01577	ORP150 Protein, Human, Recombinant (His) hypoxia up-regulated 1,HSP12A,Grp170,ORP-150,ORP150,GRP-170	Human	HEK293 Cells
	Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP15), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP6), and several isoforms of the two testis-specific HSP7 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic re...
TMPY-01589	Serpin B10 Protein, Mouse, Recombinant (His) Serpinb10-ps,serpin peptidase inhibitor, clade B (ovalbumin)...	Mouse	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi...
TMPY-02213	RAIDD Protein, Human, Recombinant (His) RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d...	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...
TMPY-02981	ING5 Protein, Human, Recombinant (GST) p28ING5,inhibitor of growth family, member 5	Human	E. coli
	ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRP...

重组蛋白

ATG5 Protein, Human, Recombinant

Cat.No: TMPJ-01329

Species: Human

Expression System: E. coli

GAS6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

HtrA2/Omi Protein, Human, Recombinant (His)

Cat.No: TMPY-02078

Species: Human

Expression System: E. coli

TMX1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05058

Species: Human

Expression System: HEK293 Cells

Granzyme B/GZMB Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00770

Species: Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01523

Species: Human & Mouse

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00276

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01554

Species: Human

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01522

Species: Human & Mouse

Expression System: HEK293 Cells

HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01548

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01549

Species: Human

Expression System: HEK293 Cells

CRADD Protein, Human, Recombinant

Cat.No: TMPJ-01059

Species: Human

Expression System: E. coli

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00277

Species: Human

Expression System: HEK293 Cells

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

Serpin I2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01841

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00365

Species: Human

Expression System: HEK293 Cells

cIAP1 Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01176

Species: Human

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

FAM3B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02640

Species: Human

Expression System: HEK293 Cells

PKCE Protein, Human, Recombinant (His)

Cat.No: TMPJ-01074

Species: Human

Expression System: E. coli

RAF1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

GAS6 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00366

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (His)

Cat.No: TMPY-04999

Species: Human

Expression System: HEK293

ZBTB17 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01097

Species: Human

Expression System: E. coli

ING4 Protein, Human, Recombinant (His)

Cat.No: TMPY-03498

Species: Human

Expression System: E. coli

OLFM4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01416

Species: Human

Expression System: HEK293 Cells

Dtk Protein, Human, Recombinant (His)

Cat.No: TMPJ-01081

Species: Human

Expression System: HEK293 Cells

AIM2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01775

Species: Human

Expression System: Baculovirus Insect Cells

BCL2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04936

Species: Human

Expression System: E. coli

ORP150 Protein, Human, Recombinant (His)

Cat.No: TMPY-01577

Species: Human

Expression System: HEK293 Cells

Serpin B10 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01589

Species: Mouse

Expression System: Baculovirus Insect Cells

RAIDD Protein, Human, Recombinant (His)

Cat.No: TMPY-02213

Species: Human

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

ING5 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02981

Species: Human

Expression System: E. coli

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